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Additionally, any non-significant differences may have been due to a lack of power rather than null effects. Five areas of significant group difference emerged for the contrast examining Scared vs. Parental history of chronic pain has been associated with self-reported pain in child offspring. While very few studies have investigated chronic pain and brain activity in pediatric populations, likely due to the challenges of neuroimaging youth 47one study in complex regional pain syndrome CRPS showed widespread cortical deactivation in the presence vs. Heightened functional connectivity of the medial prefrontal cortex MPFC with other DMN regions has been associated with pain rumination Bar graphs to illustrate one of the significant interactions are presented in Figure 3.