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Ictal headache Post-dural-puncture headache. However, headaches associated with sexual activity can be anything but a joke. Kraft, Natural course of benign coital headache. Headaches associated with or occurring around sexual activity have been recognized since the time of Hippocrates [1, 2]. Prevention While some occurrences of sexual headaches may be unavoidable, there are multiple steps a person can take in an effort to reduce their chances of experiencing sexual headaches. N Engl J Med, Views Read Edit View history. Neurol Clin N Am, Evers and his colleagues are careful to only speculate that the endorphins released during orgasm are the primary reason for the pain relief.