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A gush of blood from the vagina may be seen right before the baby is born. Sexually Transmitted Infections - E-book. An Invitation to Health Brief Cancer and sexual health. While these symptoms are likelier to happen after labor has begun for women who have given birth before, they may happen ten to fourteen days before labor in women experiencing labor for the first time. Pharmacologicallythis has the potential advantage of promoting therapeutic effects primarily in the vagina or nearby structures such as the vaginal portion of cervix with limited systemic adverse effects compared to other routes of administration.